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Age-related changes of the skin are thought to be driven by two basic mechanisms: biological aging and exposure to ultraviolet rays (photoaging)

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The second part of the study began by randomly dividing the test subjects in three groups including: APP/PS1, Dihexa administered at a dose of 2.88 mg/kg, and 2.88 mg/kg of Dihexa + 0.5 mg/kg of wortmannin